PrenatalSAFE Complete Plus is our most comprehensive non-invasive prenatal test: everything in Karyo Plus, every chromosome and nine microdeletion syndromes, plus screening for five inherited genetic diseases and up to 50 de novo genetic conditions such as Noonan syndrome and achondroplasia, from one blood sample from 10 weeks. No risk to your baby. From £1,545, with a pre-test consultation and free genetic counselling included. Results arrive in two clear stages.
Three layers. First, the chromosomes: every one checked for extra or missing copies and large deletions or duplications, including Down's, Edwards', Patau and the four sex chromosome conditions. Second, nine microdeletion syndromes including DiGeorge, Prader-Willi and Angelman. Third, and unique to this test, single-gene conditions: five inherited diseases including cystic fibrosis, sickle cell anaemia, beta thalassaemia and hereditary deafness, and up to 50 de novo conditions, new genetic changes not carried by either parent, such as Noonan syndrome, achondroplasia, osteogenesis imperfecta and some forms of Ehlers-Danlos syndrome.
Conditions caused by a new change in a single gene that arose in the egg, the sperm or just after conception, and is not present in either parent. Because they are not inherited, a family history offers no warning and standard carrier testing cannot predict them. Individually each is rare. Many affect bone growth, the heart or development, and knowing before birth allows planning of delivery and early care.
Cystic fibrosis, sickle cell anaemia, beta thalassaemia and hereditary deafness are recessive conditions: a baby is affected only if it inherits a faulty copy of the gene from both parents. The test looks for these variants in the placental DNA in your blood. Because your own DNA is also present, a cheek swab from the baby's father lets the laboratory tell which variants came from him and cross-check anything found, which strengthens the result. The swab is included in the kit, optional, and strongly recommended.
Because this test screens for conditions most people have never heard of, and a high-chance result for a rare genetic disease needs context before, not just after, testing. A Goodbody clinician talks through what the test can and cannot tell you, checks your dates and any family history, explains the two-stage results and the father's swab, and answers your questions. It is required before the blood draw appointment and is included in the price.
The chromosome and microdeletion analysis is the same as PrenatalSAFE Karyo Plus and is reported first, in about 10 working days. The single-gene analysis, which sequences dozens of individual genes and compares them against the father's swab where provided, takes longer and is reported in about 20 working days. You are not kept waiting for the most common conditions while the rarer ones are analysed.
For the chromosomal conditions, as accurate as our other PrenatalSAFE tests. For the single-gene conditions, detection depends on the amount of placental DNA and the specific variant, and because the conditions are rare, a high-chance result must be confirmed by diagnostic testing before it is treated as a diagnosis. A low-chance result greatly reduces but does not eliminate the chance of these conditions, and the test does not screen for every genetic disease. The included genetic counselling exists precisely to put any result in context.
No. NIPT is a screening test. It reads fragments of placental DNA in your blood and reports whether the chance of each condition is high or low. Because placental DNA occasionally differs from the baby's, a high-chance result must be confirmed with a diagnostic test, chorionic villus sampling or amniocentesis, before any decision is made, and the NHS will arrange that. A low-chance result is strongly reassuring but not a guarantee, and it does not screen for every condition or for structural problems, which the 20-week scan looks for.
You are contacted personally rather than simply emailed, and offered a consultation with a professional genetic counsellor at no extra cost, included in the price of every PrenatalSAFE test. The counsellor explains exactly what the result means for your pregnancy, the confirmatory options available on the NHS, and the timescales, and can talk to your midwife or consultant. You are not left to interpret a report alone.
IVF pregnancies, including those from donor eggs, are fine for every PrenatalSAFE test. Twins are more limited: with identical twins (one placenta) all results including sex can be reported; with non-identical twins (two placentas) the baby's sex is not reported, and sex chromosome conditions are not reported for any twin pregnancy. Single-gene results in twin pregnancies are more limited; discuss with us before booking. A vanishing twin, where one of two embryos stopped developing early, also affects what can be reported; tell us when you book.
Parents who want the widest screen a blood test can offer, particularly where there is a family history of a genetic condition, where the parents are related, where an earlier pregnancy or child was affected by a rare condition, or where the father is older, since de novo conditions become more common with paternal age. It is also chosen by parents who simply want to know as much as possible before birth. Our pre-test consultation helps you decide whether the full panel is right for you or whether Karyo Plus would answer your questions.
£1,545 at one of 250+ Goodbody clinics or £1,565 with a nurse home visit, including the pre-test consultation, the collection kit with paternal swab, laboratory analysis in two stages, your reports and genetic counselling for any high-chance result. Comparable extended NIPT panels in the UK cost £1,400 to £2,000 where they are available at all.
Choose by how much you want to know:
| Test | Screens for | Price | Results |
|---|---|---|---|
| PrenatalSAFE 3 | Down's, Edwards' and Patau syndromes, and your baby's sex | from £315 | 3 to 5 working days |
| PrenatalSAFE 5 | Everything in 3, plus Turner, Klinefelter, Triple X and Jacobs syndromes (sex chromosome conditions) | from £375 | 3 to 5 working days |
| PrenatalSAFE Karyo | Everything in 5, plus every chromosome checked for extra or missing copies and for deletions or duplications over 7 Mb | from £645 | 5 to 7 working days |
| PrenatalSAFE Karyo Plus | Everything in Karyo, plus 9 microdeletion syndromes including DiGeorge, Prader-Willi and Angelman | from £795 | 10 to 12 working days |
| PrenatalSAFE Complete Plus | Everything in Karyo Plus, plus 5 inherited genetic diseases and up to 50 de novo conditions | from £1,545 | 10 then 20 working days |
Your results are emailed in two stages: the chromosomal and microdeletion report about 10 working days after your sample reaches the laboratory, and the genetic disease report about 20 working days after. Each states clearly whether the chance of each condition is low or high. If any result is high chance you are contacted personally and offered a consultation with a professional genetic counsellor at no extra cost, who explains the result and the confirmatory testing available through the NHS. All samples are analysed by a UKAS-accredited laboratory.
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Compare NIPT tests
All Goodbody NIPT tests use a simple, safe blood sample from 10 weeks. The right one for you depends on how much you want to know.
| Compare tests |
PrenatalSAFE 3
From
£315
View test
|
PrenatalSAFE 5
From
£375
View test
|
PrenatalSAFE Karyo
From
£645
View test
|
Most comprehensive
PrenatalSAFE Complete Plus
From
£1,545
Your selection
| |
|---|---|---|---|---|---|
| Conditions screened | 3 | 7 | 10 | 19 | 21+ |
| Down, Edwards & Patau syndrome Trisomy 21, 18 & 13 | |||||
| Sex chromosome disorders Turner, Klinefelter, Jacobs | |||||
| All 23 chromosome pairs Aneuploidies, deletions & duplications | |||||
| 9 microdeletion syndromes Prader-Willi, Angelman, DiGeorge & more | |||||
| 5 inherited genetic diseases Cystic fibrosis, sickle cell, thalassemia, deafness | |||||
| ~50 De Novo diseases Spontaneous mutations not inherited from parents | |||||
| Gender identification Single pregnancies & identical twins | |||||
| Twin pregnancy | |||||
| Results turnaround | 3–5 working days | 3–5 working days | 5–7 working days | 10–12 working days | Staged: 10 & 20 working days |
| From pregnancy week | 10 weeks | 10 weeks | 10 weeks | 10 weeks | 10 weeks |
| Sample collection | In-clinic or at home | In-clinic or at home | In-clinic or at home | In-clinic or at home | In-clinic or at home |
| Free post-test genetic counselling Included with every positive result | |||||
| Price (from) | £315 | £375 | £645 | £795 | £1,545 |
| Choose test | Choose | Choose | Choose | Choose | Your selection |
All prices are for in-clinic appointments. Home visits available at a small additional cost. Free post-test genetic counselling is included with every test should a positive result arise.
Meet the clinical lead
This is the safest and easiest way to find out the gender or check the genetic health of your baby during pregnancy, with FREE genetic counselling provided if you receive a positive result for any health condition. We provide a specialised testing kit to take with you to your appointment and a FREE pre-consultation on Karyo, Karyo Plus, and Complete Plus Tests.
Book online, receive your kit and take to your local Goodbody clinic.
Send your sample in the post to be analysed at an accredited laboratory.
Get your comprehensive detailed results report from the laboratory, with guidance from our support team.
Suitable for women of all ages, of at least 10 weeks of gestation (at the time of their blood draw appointment), who have had their pregnancy type (single or twin) previously confirmed by an ultrasound scan. The pregnancy can be naturally conceived or through IVF.
Our genetic health tests are called NIPT tests, or Non-Invasive Prenatal Tests. An NIPT is a blood test taken from the mother during pregnancy, using state of the art DNA technology to check whether the baby has high risks of certain chromosomal health conditions.
During pregnancy the placenta sheds cell free DNA (cfDNA) into the mother’s bloodstream. This means that the mother’s blood continues a mixture of your own DNA, and that of your baby’s placenta. By extracting and evaluating the cfDNA in your blood, we can identify the risk to your baby of a range of health conditions and diseases.
Enquire via the form and a member of our team will get back to you, they are more than happy to help answer your questions and talk through the best option for you.
Contact us if you aren't sure, we'd be happy to help!
PLACING AN ORDER
ARRANGING AN APPOINTMENT
AFTER YOUR TEST
When you’re worried about your health, life can feel very stressful, especially if you don’t have the answers you need. We believe that health testing should be available to all, giving you answers when and where you need them.
That’s why we’ve partnered with Splitit, Dopple and Clearpay so you can pay for your tests in interest-free instalments, if you prefer.
